null

SMILES: CC(=O)N1CCN(CC1)c1cccc(c1)-c1cc(-c2ccnn2C2COC2)c2c(N)ncnn12

InChI Key: InChIKey=FMZCAHXYZKLKNJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50232448   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50232448 (CHEMBL4072625) Show SMILES CC(=O)N1CCN(CC1)c1cccc(c1)-c1cc(-c2ccnn2C2COC2)c2c(N)ncnn12 Show InChI InChI=1S/C24H26N8O2/c1-16(33)29-7-9-30(10-8-29)18-4-2-3-17(11-18)22-12-20(23-24(25)26-15-28-32(22)23)21-5-6-27-31(21)19-13-34-14-19/h2-6,11-12,15,19H,7-10,13-14H2,1H3,(H2,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assay				Bioorg Med Chem Lett 27: 855-861 (2017) BindingDB Entry DOI: 10.7270/Q2BR8VFH
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50232448 (CHEMBL4072625) Show SMILES CC(=O)N1CCN(CC1)c1cccc(c1)-c1cc(-c2ccnn2C2COC2)c2c(N)ncnn12 Show InChI InChI=1S/C24H26N8O2/c1-16(33)29-7-9-30(10-8-29)18-4-2-3-17(11-18)22-12-20(23-24(25)26-15-28-32(22)23)21-5-6-27-31(21)19-13-34-14-19/h2-6,11-12,15,19H,7-10,13-14H2,1H3,(H2,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human whole blood assessed as suppression of CD69 expression incubated for 60 mins				Bioorg Med Chem Lett 27: 855-861 (2017) BindingDB Entry DOI: 10.7270/Q2BR8VFH
					More data for this Ligand-Target Pair