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SMILES: O=C(Nc1ccc(cc1)-c1ccccc1)[C@H]1CCCN1c1ccc(cc1)-n1ccnc1

InChI Key: InChIKey=NKGJSYNBNHQSCL-RUZDIDTESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50233632   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens (Human))		BDBM50233632
PNG
(CHEMBL4069613)
Show SMILES O=C(Nc1ccc(cc1)-c1ccccc1)[C@H]1CCCN1c1ccc(cc1)-n1ccnc1 |r|
Show InChI InChI=1S/C26H24N4O/c31-26(28-22-10-8-21(9-11-22)20-5-2-1-3-6-20)25-7-4-17-30(25)24-14-12-23(13-15-24)29-18-16-27-19-29/h1-3,5-6,8-16,18-19,25H,4,7,17H2,(H,28,31)/t25-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 3.30E+4n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...

J Med Chem 58: 5889-99 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00507
BindingDB Entry DOI: 10.7270/Q29K4DG1
More data for this
Ligand-Target Pair