BDBM50233988 CHEMBL4097252

SMILES: Cc1ccn(n1)-c1cc(ccc1[C@@H](Oc1cc(nc(N)n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1)C(F)(F)F)-c1ccc(C)c(C)c1

InChI Key: InChIKey=LMQXNFPPXYNHLH-ABYGYWHVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50233988   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM50233988 (CHEMBL4097252) Show SMILES Cc1ccn(n1)-c1cc(ccc1[C@@H](Oc1cc(nc(N)n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1)C(F)(F)F)-c1ccc(C)c(C)c1 |r| Show InChI InChI=1S/C33H36F3N7O3/c1-19-4-5-22(14-20(19)2)23-6-7-24(26(15-23)43-11-8-21(3)41-43)29(33(34,35)36)46-28-16-27(39-31(37)40-28)42-12-9-32(10-13-42)17-25(30(44)45)38-18-32/h4-8,11,14-16,25,29,38H,9-10,12-13,17-18H2,1-3H3,(H,44,45)(H2,37,39,40)/t25-,29+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Karos Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of TPH1 (unknown origin)				Bioorg Med Chem Lett 27: 413-419 (2017) BindingDB Entry DOI: 10.7270/Q21V5H7S
					More data for this Ligand-Target Pair