BDBM50234141 CHEMBL4083866

SMILES: Cc1n[nH]c(C)c1-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1

InChI Key: InChIKey=RYEDWDSERPNXBB-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50234141   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphoinositide 3-Kinase (PI3K), delta (Homo sapiens (Human))	BDBM50234141 (CHEMBL4083866) Show SMILES Cc1n[nH]c(C)c1-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 |(25.94,-39.46,;25.61,-37.95,;26.63,-36.8,;25.86,-35.48,;24.36,-35.81,;23.2,-34.79,;24.21,-37.34,;22.88,-38.12,;21.55,-37.36,;20.22,-38.13,;20.22,-39.67,;21.55,-40.44,;22.89,-39.67,;24.22,-40.44,;18.88,-37.35,;18.72,-35.82,;17.22,-35.5,;16.45,-36.83,;14.92,-36.99,;17.48,-37.98,;16.54,-34.1,;15.21,-34.87,;15.21,-33.33,;17.29,-32.76,;18.83,-32.73,;19.57,-31.39,;18.78,-30.06,;17.23,-30.1,;16.49,-31.45,)| Show InChI InChI=1S/C21H22N8/c1-12-16(13(2)27-26-12)17-18(22)23-11-15(24-17)19-25-20(29(3)28-19)21(9-10-21)14-7-5-4-6-8-14/h4-8,11H,9-10H2,1-3H3,(H2,22,23)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...				Bioorg Med Chem Lett 27: 679-687 (2017) BindingDB Entry DOI: 10.7270/Q2TF00MM
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50234141 (CHEMBL4083866) Show SMILES Cc1n[nH]c(C)c1-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 |(25.94,-39.46,;25.61,-37.95,;26.63,-36.8,;25.86,-35.48,;24.36,-35.81,;23.2,-34.79,;24.21,-37.34,;22.88,-38.12,;21.55,-37.36,;20.22,-38.13,;20.22,-39.67,;21.55,-40.44,;22.89,-39.67,;24.22,-40.44,;18.88,-37.35,;18.72,-35.82,;17.22,-35.5,;16.45,-36.83,;14.92,-36.99,;17.48,-37.98,;16.54,-34.1,;15.21,-34.87,;15.21,-33.33,;17.29,-32.76,;18.83,-32.73,;19.57,-31.39,;18.78,-30.06,;17.23,-30.1,;16.49,-31.45,)| Show InChI InChI=1S/C21H22N8/c1-12-16(13(2)27-26-12)17-18(22)23-11-15(24-17)19-25-20(29(3)28-19)21(9-10-21)14-7-5-4-6-8-14/h4-8,11H,9-10H2,1-3H3,(H2,22,23)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr...				Bioorg Med Chem Lett 27: 679-687 (2017) BindingDB Entry DOI: 10.7270/Q2TF00MM
					More data for this Ligand-Target Pair
p110β/p85α (Homo sapiens (Human))	BDBM50234141 (CHEMBL4083866) Show SMILES Cc1n[nH]c(C)c1-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 |(25.94,-39.46,;25.61,-37.95,;26.63,-36.8,;25.86,-35.48,;24.36,-35.81,;23.2,-34.79,;24.21,-37.34,;22.88,-38.12,;21.55,-37.36,;20.22,-38.13,;20.22,-39.67,;21.55,-40.44,;22.89,-39.67,;24.22,-40.44,;18.88,-37.35,;18.72,-35.82,;17.22,-35.5,;16.45,-36.83,;14.92,-36.99,;17.48,-37.98,;16.54,-34.1,;15.21,-34.87,;15.21,-33.33,;17.29,-32.76,;18.83,-32.73,;19.57,-31.39,;18.78,-30.06,;17.23,-30.1,;16.49,-31.45,)| Show InChI InChI=1S/C21H22N8/c1-12-16(13(2)27-26-12)17-18(22)23-11-15(24-17)19-25-20(29(3)28-19)21(9-10-21)14-7-5-4-6-8-14/h4-8,11H,9-10H2,1-3H3,(H2,22,23)(H,26,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	<3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi...				Bioorg Med Chem Lett 27: 679-687 (2017) BindingDB Entry DOI: 10.7270/Q2TF00MM
					More data for this Ligand-Target Pair
p110α/p85α (Homo sapiens (Human))	BDBM50234141 (CHEMBL4083866) Show SMILES Cc1n[nH]c(C)c1-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 |(25.94,-39.46,;25.61,-37.95,;26.63,-36.8,;25.86,-35.48,;24.36,-35.81,;23.2,-34.79,;24.21,-37.34,;22.88,-38.12,;21.55,-37.36,;20.22,-38.13,;20.22,-39.67,;21.55,-40.44,;22.89,-39.67,;24.22,-40.44,;18.88,-37.35,;18.72,-35.82,;17.22,-35.5,;16.45,-36.83,;14.92,-36.99,;17.48,-37.98,;16.54,-34.1,;15.21,-34.87,;15.21,-33.33,;17.29,-32.76,;18.83,-32.73,;19.57,-31.39,;18.78,-30.06,;17.23,-30.1,;16.49,-31.45,)| Show InChI InChI=1S/C21H22N8/c1-12-16(13(2)27-26-12)17-18(22)23-11-15(24-17)19-25-20(29(3)28-19)21(9-10-21)14-7-5-4-6-8-14/h4-8,11H,9-10H2,1-3H3,(H2,22,23)(H,26,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	<3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...				Bioorg Med Chem Lett 27: 679-687 (2017) BindingDB Entry DOI: 10.7270/Q2TF00MM
					More data for this Ligand-Target Pair