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SMILES: CN1CCC(CC1)n1cc(Nc2ncc3c(C)cc(=O)n(-c4cccc(NC(=O)C=C)c4)c3n2)cn1

InChI Key: InChIKey=KHOYQSYTAMJNTQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50234182   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50234182
PNG
(CHEMBL4064475)
Show SMILES CN1CCC(CC1)n1cc(Nc2ncc3c(C)cc(=O)n(-c4cccc(NC(=O)C=C)c4)c3n2)cn1
Show InChI InChI=1S/C26H28N8O2/c1-4-23(35)29-18-6-5-7-21(13-18)34-24(36)12-17(2)22-15-27-26(31-25(22)34)30-19-14-28-33(16-19)20-8-10-32(3)11-9-20/h4-7,12-16,20H,1,8-11H2,2-3H3,(H,29,35)(H,27,30,31)
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Similars
PubMed
n/an/a 166n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL


Assay Description
Inhibition of N-terminal 6His/TEV protease cleavage site-tagged wild type human EGFR using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA

Eur J Med Chem 126: 1107-1117 (2017)


BindingDB Entry DOI: 10.7270/Q2F47RD5
More data for this
Ligand-Target Pair