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SMILES: COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cc(NC(=O)C=C)cc(c3)C(C)C)c2n1)N1CCN(C)CC1

InChI Key: InChIKey=NTASYPAHYBVDOK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50234190   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50234190
PNG
(CHEMBL4079861)
Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cc(NC(=O)C=C)cc(c3)C(C)C)c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C32H37N7O3/c1-7-29(40)34-23-15-22(20(2)3)16-25(17-23)39-30(41)14-21(4)26-19-33-32(36-31(26)39)35-27-9-8-24(18-28(27)42-6)38-12-10-37(5)11-13-38/h7-9,14-20H,1,10-13H2,2-6H3,(H,34,40)(H,33,35,36)
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KEGG

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Similars
PubMed
n/an/a 24n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL


Assay Description
Inhibition of N-terminal 6His/TEV protease cleavage site-tagged wild type human EGFR using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA

Eur J Med Chem 126: 1107-1117 (2017)


BindingDB Entry DOI: 10.7270/Q2F47RD5
More data for this
Ligand-Target Pair