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SMILES: COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(C)C(C)C1

InChI Key: InChIKey=KOSYHFYRKSADPR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50234195   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50234195
PNG
(CHEMBL4091276)
Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(C)C(C)C1
Show InChI InChI=1S/C30H33N7O3/c1-6-27(38)32-21-8-7-9-23(15-21)37-28(39)14-19(2)24-17-31-30(34-29(24)37)33-25-11-10-22(16-26(25)40-5)36-13-12-35(4)20(3)18-36/h6-11,14-17,20H,1,12-13,18H2,2-5H3,(H,32,38)(H,31,33,34)
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Similars
PubMed
n/an/a 169n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL


Assay Description
Inhibition of N-terminal 6His/TEV protease cleavage site-tagged wild type human EGFR using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA

Eur J Med Chem 126: 1107-1117 (2017)


BindingDB Entry DOI: 10.7270/Q2F47RD5
More data for this
Ligand-Target Pair