BDBM50234202 CHEMBL4072840

SMILES: Nc1nc(O[C@H](c2ccc(Cl)cc2-c2cccc(c2)C(F)(F)F)C(F)(F)F)cc(n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1

InChI Key: InChIKey=UBUINLZAVPGKNX-NZQKXSOJSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50234202   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM50234202 (CHEMBL4072840) Show SMILES Nc1nc(O[C@H](c2ccc(Cl)cc2-c2cccc(c2)C(F)(F)F)C(F)(F)F)cc(n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1 |r| Show InChI InChI=1S/C28H26ClF6N5O3/c29-17-4-5-18(19(11-17)15-2-1-3-16(10-15)27(30,31)32)23(28(33,34)35)43-22-12-21(38-25(36)39-22)40-8-6-26(7-9-40)13-20(24(41)42)37-14-26/h1-5,10-12,20,23,37H,6-9,13-14H2,(H,41,42)(H2,36,38,39)/t20-,23+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Karos Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of TPH1 (unknown origin)				Bioorg Med Chem Lett 27: 413-419 (2017) BindingDB Entry DOI: 10.7270/Q21V5H7S
					More data for this Ligand-Target Pair