BDBM50234574 CHEMBL4105491

SMILES: CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cncc4ccccc34)cc2C(F)(F)F)CC1

InChI Key: InChIKey=YWKSYTCBEVSAAX-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50234574   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50234574 (CHEMBL4105491) Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cncc4ccccc34)cc2C(F)(F)F)CC1 Show InChI InChI=1S/C32H29F3N4O/c1-22-7-8-24(17-23(22)9-10-26-20-36-19-25-5-3-4-6-29(25)26)31(40)37-28-12-11-27(30(18-28)32(33,34)35)21-39-15-13-38(2)14-16-39/h3-8,11-12,17-20H,13-16,21H2,1-2H3,(H,37,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant KDR (unknown origin) using poly (Glu, Tyr) 4:1 after 60 mins by ELISA method				Eur J Med Chem 126: 122-132 (2017) BindingDB Entry DOI: 10.7270/Q2FX7CQK
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50234574 (CHEMBL4105491) Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cncc4ccccc34)cc2C(F)(F)F)CC1 Show InChI InChI=1S/C32H29F3N4O/c1-22-7-8-24(17-23(22)9-10-26-20-36-19-25-5-3-4-6-29(25)26)31(40)37-28-12-11-27(30(18-28)32(33,34)35)21-39-15-13-38(2)14-16-39/h3-8,11-12,17-20H,13-16,21H2,1-2H3,(H,37,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged FGFR1 (456 to 765 residues) expressed in baculovirus infected Sf21 insect cells using poly (Glu...				J Med Chem 63: 1397-1414 (2020) Article DOI: 10.1021/acs.jmedchem.9b01912
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50234574 (CHEMBL4105491) Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cncc4ccccc34)cc2C(F)(F)F)CC1 Show InChI InChI=1S/C32H29F3N4O/c1-22-7-8-24(17-23(22)9-10-26-20-36-19-25-5-3-4-6-29(25)26)31(40)37-28-12-11-27(30(18-28)32(33,34)35)21-39-15-13-38(2)14-16-39/h3-8,11-12,17-20H,13-16,21H2,1-2H3,(H,37,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant CSF1R (unknown origin) using poly (Glu, Tyr)4:1 as substrate measured after 1 hr by ELISA				J Med Chem 63: 1397-1414 (2020) Article DOI: 10.1021/acs.jmedchem.9b01912
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50234574 (CHEMBL4105491) Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cncc4ccccc34)cc2C(F)(F)F)CC1 Show InChI InChI=1S/C32H29F3N4O/c1-22-7-8-24(17-23(22)9-10-26-20-36-19-25-5-3-4-6-29(25)26)31(40)37-28-12-11-27(30(18-28)32(33,34)35)21-39-15-13-38(2)14-16-39/h3-8,11-12,17-20H,13-16,21H2,1-2H3,(H,37,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu, Tyr) 4:1 after 60 mins by ELISA method				Eur J Med Chem 126: 122-132 (2017) BindingDB Entry DOI: 10.7270/Q2FX7CQK
					More data for this Ligand-Target Pair