BDBM50235192 CHEMBL4073876

SMILES: CN1C(=O)Cc2cc(ccc12)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccc(F)cc2F)c1

InChI Key: InChIKey=VLUNDCWIZVPHIH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50235192   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Perforin-1 (Homo sapiens (Human))	BDBM50235192 (CHEMBL4073876) Show SMILES CN1C(=O)Cc2cc(ccc12)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccc(F)cc2F)c1 Show InChI InChI=1S/C24H17F2N3O3S2/c1-29-20-4-2-14(8-15(20)10-24(29)30)21-5-6-22(33-21)16-9-18(13-27-12-16)28-34(31,32)23-7-3-17(25)11-19(23)26/h2-9,11-13,28H,10H2,1H3	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin) assessed as decrease in lysis of 51Cr-labelled human Jurkat cells by measuring 51Cr release prein...				Bioorg Med Chem Lett 27: 1050-1054 (2017) Article DOI: 10.1016/j.bmcl.2016.12.057 BindingDB Entry DOI: 10.7270/Q2XS5XNH
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