BDBM50235285 CHEMBL4101316

SMILES: COCCNCc1ccc2ccc(Cl)c(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1

InChI Key: InChIKey=LPIHDMXDUPXXEU-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50235285   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C, PKC; classical/novel (Homo sapiens (Human))	BDBM50235285 (CHEMBL4101316) Show SMILES COCCNCc1ccc2ccc(Cl)c(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1 |t:15| Show InChI InChI=1S/C27H24ClN3O3/c1-31-15-20(18-5-3-4-6-22(18)31)24-25(27(33)30-26(24)32)23-19-13-16(14-29-11-12-34-2)7-8-17(19)9-10-21(23)28/h3-10,13,15,29H,11-12,14H2,1-2H3,(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCepsilon (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay				Bioorg Med Chem Lett 27: 781-786 (2017) Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1
					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50235285 (CHEMBL4101316) Show SMILES COCCNCc1ccc2ccc(Cl)c(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1 |t:15| Show InChI InChI=1S/C27H24ClN3O3/c1-31-15-20(18-5-3-4-6-22(18)31)24-25(27(33)30-26(24)32)23-19-13-16(14-29-11-12-34-2)7-8-17(19)9-10-21(23)28/h3-10,13,15,29H,11-12,14H2,1-2H3,(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCalpha (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay				Bioorg Med Chem Lett 27: 781-786 (2017) Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1
					More data for this Ligand-Target Pair
Protein kinase C, PKC; classical/novel (Homo sapiens (Human))	BDBM50235285 (CHEMBL4101316) Show SMILES COCCNCc1ccc2ccc(Cl)c(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1 |t:15| Show InChI InChI=1S/C27H24ClN3O3/c1-31-15-20(18-5-3-4-6-22(18)31)24-25(27(33)30-26(24)32)23-19-13-16(14-29-11-12-34-2)7-8-17(19)9-10-21(23)28/h3-10,13,15,29H,11-12,14H2,1-2H3,(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	206	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCeta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay				Bioorg Med Chem Lett 27: 781-786 (2017) Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1
					More data for this Ligand-Target Pair
Protein kinase C, PKC; classical/novel (Homo sapiens (Human))	BDBM50235285 (CHEMBL4101316) Show SMILES COCCNCc1ccc2ccc(Cl)c(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1 |t:15| Show InChI InChI=1S/C27H24ClN3O3/c1-31-15-20(18-5-3-4-6-22(18)31)24-25(27(33)30-26(24)32)23-19-13-16(14-29-11-12-34-2)7-8-17(19)9-10-21(23)28/h3-10,13,15,29H,11-12,14H2,1-2H3,(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCdelta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay				Bioorg Med Chem Lett 27: 781-786 (2017) Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50235285 (CHEMBL4101316) Show SMILES COCCNCc1ccc2ccc(Cl)c(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1 |t:15| Show InChI InChI=1S/C27H24ClN3O3/c1-31-15-20(18-5-3-4-6-22(18)31)24-25(27(33)30-26(24)32)23-19-13-16(14-29-11-12-34-2)7-8-17(19)9-10-21(23)28/h3-10,13,15,29H,11-12,14H2,1-2H3,(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCtheta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay				Bioorg Med Chem Lett 27: 781-786 (2017) Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1
					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50235285 (CHEMBL4101316) Show SMILES COCCNCc1ccc2ccc(Cl)c(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1 |t:15| Show InChI InChI=1S/C27H24ClN3O3/c1-31-15-20(18-5-3-4-6-22(18)31)24-25(27(33)30-26(24)32)23-19-13-16(14-29-11-12-34-2)7-8-17(19)9-10-21(23)28/h3-10,13,15,29H,11-12,14H2,1-2H3,(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCbeta1 (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay				Bioorg Med Chem Lett 27: 781-786 (2017) Article DOI: 10.1016/j.bmcl.2017.01.038 BindingDB Entry DOI: 10.7270/Q2930WF1
					More data for this Ligand-Target Pair