BDBM50235997 CHEMBL4105572

SMILES: CN(C)Cc1ccc(cc1)-c1cnc(NCc2ccoc2)n2cnnc12

InChI Key: InChIKey=QHMXUQUHMYTQSI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50235997   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polycomb protein EED (Homo sapiens (Human))	BDBM50235997 (CHEMBL4105572) Show SMILES CN(C)Cc1ccc(cc1)-c1cnc(NCc2ccoc2)n2cnnc12 Show InChI InChI=1S/C19H20N6O/c1-24(2)11-14-3-5-16(6-4-14)17-10-21-19(25-13-22-23-18(17)25)20-9-15-7-8-26-12-15/h3-8,10,12-13H,9,11H2,1-2H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of EED in human G401 cells assessed as reduction in global H3K27me3 level after 48 hrs by ELISA				J Med Chem 60: 2215-2226 (2017) Article DOI: 10.1021/acs.jmedchem.6b01576 BindingDB Entry DOI: 10.7270/Q20G3NDT
					More data for this Ligand-Target Pair