BDBM50236022 CHEMBL4097028

SMILES: CN(C)Cc1ccc(cc1)-c1cnc(NCc2ccc(C)s2)n2cnnc12

InChI Key: InChIKey=ORRVEKJGHPHCRM-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50236022   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polycomb protein EED (Homo sapiens (Human))	BDBM50236022 (CHEMBL4097028) Show SMILES CN(C)Cc1ccc(cc1)-c1cnc(NCc2ccc(C)s2)n2cnnc12 Show InChI InChI=1S/C20H22N6S/c1-14-4-9-17(27-14)10-21-20-22-11-18(19-24-23-13-26(19)20)16-7-5-15(6-8-16)12-25(2)3/h4-9,11,13H,10,12H2,1-3H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL asses...				J Med Chem 60: 2215-2226 (2017) Article DOI: 10.1021/acs.jmedchem.6b01576 BindingDB Entry DOI: 10.7270/Q20G3NDT
					More data for this Ligand-Target Pair