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BDBM50237015 CHEMBL4063816

SMILES: Fc1cnc(nc1N(CCOc1ccc2ccccc2c1)Cc1ccc2OCOc2c1)C#N

InChI Key: InChIKey=GYOJYEHUZLLOFH-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50237015   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Procathepsin L


(Homo sapiens (Human))		BDBM50237015
PNG
(CHEMBL4063816)
Show SMILES Fc1cnc(nc1N(CCOc1ccc2ccccc2c1)Cc1ccc2OCOc2c1)C#N
Show InChI InChI=1S/C25H19FN4O3/c26-21-14-28-24(13-27)29-25(21)30(15-17-5-8-22-23(11-17)33-16-32-22)9-10-31-20-7-6-18-3-1-2-4-19(18)12-20/h1-8,11-12,14H,9-10,15-16H2
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MMDB

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 123n/an/an/an/an/an/an/an/a



Roche Pharmaceutical Research and Early Development (pRED)

Curated by ChEMBL


Assay Description
Inhibition of human Cathepsin L by fluorescence assay based Cheng-Prusoff equation analysis

J Med Chem 60: 2485-2497 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01881
BindingDB Entry DOI: 10.7270/Q2PV6NN3
More data for this
Ligand-Target Pair