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SMILES: Clc1ccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1

InChI Key: InChIKey=CPISIOQAKTUKSO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50237096   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50237096
PNG
(CHEMBL4097862)
Show SMILES Clc1ccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1
Show InChI InChI=1S/C21H15BrClN5S/c22-13-2-1-3-16(10-13)26-20-18-11-17(8-9-19(18)24-12-25-20)28-21(29)27-15-6-4-14(23)5-7-15/h1-12H,(H,24,25,26)(H2,27,28,29)
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Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system

J Med Chem 60: 2853-2868 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP
More data for this
Ligand-Target Pair