BDBM50237111 CHEMBL4103464

SMILES: Brc1cccc(Nc2ncnc3ccc(NC(=O)NCc4ccccc4)cc23)c1

InChI Key: InChIKey=KSRUPTRACAQHLQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50237111   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50237111 (CHEMBL4103464) Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)NCc4ccccc4)cc23)c1 Show InChI InChI=1S/C22H18BrN5O/c23-16-7-4-8-17(11-16)27-21-19-12-18(9-10-20(19)25-14-26-21)28-22(29)24-13-15-5-2-1-3-6-15/h1-12,14H,13H2,(H2,24,28,29)(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system				J Med Chem 60: 2853-2868 (2017) Article DOI: 10.1021/acs.jmedchem.6b01774 BindingDB Entry DOI: 10.7270/Q2K35WXP
					More data for this Ligand-Target Pair