BDBM50237753 CHEMBL4085388

SMILES: CN1[C@H]([C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc23)C11CCCCC1)c1nc(co1)C(O)=O

InChI Key: InChIKey=SDQGKDMQMLBURH-ZVUIFXONSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50237753   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50237753 (CHEMBL4085388) Show SMILES CN1[C@H]([C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc23)C11CCCCC1)c1nc(co1)C(O)=O |r| Show InChI InChI=1S/C27H24Cl2FN3O4/c1-33-22(23-31-19(13-37-23)24(34)35)20(15-6-5-7-17(29)21(15)30)27(26(33)10-3-2-4-11-26)16-9-8-14(28)12-18(16)32-25(27)36/h5-9,12-13,20,22H,2-4,10-11H2,1H3,(H,32,36)(H,34,35)/t20-,22+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center Curated by ChEMBL					Assay Description Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptor				J Med Chem 60: 2819-2839 (2017) Article DOI: 10.1021/acs.jmedchem.6b01665 BindingDB Entry DOI: 10.7270/Q25Q4ZCF
					More data for this Ligand-Target Pair
MDM2-MDMX (Homo sapiens (Human))	BDBM50237753 (CHEMBL4085388) Show SMILES CN1[C@H]([C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc23)C11CCCCC1)c1nc(co1)C(O)=O |r| Show InChI InChI=1S/C27H24Cl2FN3O4/c1-33-22(23-31-19(13-37-23)24(34)35)20(15-6-5-7-17(29)21(15)30)27(26(33)10-3-2-4-11-26)16-9-8-14(28)12-18(16)32-25(27)36/h5-9,12-13,20,22H,2-4,10-11H2,1H3,(H,32,36)(H,34,35)/t20-,22+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center Curated by ChEMBL					Assay Description Inhibition of FAM-tagged p53-based PMDM6-F peptide binding to human recombinant His-tagged MDM2 (1 to 118 residues) after 30 mins by fluorescence pol...				J Med Chem 60: 2819-2839 (2017) Article DOI: 10.1021/acs.jmedchem.6b01665 BindingDB Entry DOI: 10.7270/Q25Q4ZCF
					More data for this Ligand-Target Pair