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SMILES: Fc1ccc(cc1)-c1nc(SCCCNC(=O)C=C)[nH]c1-c1ccnc(Nc2ccccc2)c1

InChI Key: InChIKey=VJSUVZXKMROKMD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50238161   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50238161
PNG
(CHEMBL4089601)
Show SMILES Fc1ccc(cc1)-c1nc(SCCCNC(=O)C=C)[nH]c1-c1ccnc(Nc2ccccc2)c1
Show InChI InChI=1S/C26H24FN5OS/c1-2-23(33)29-14-6-16-34-26-31-24(18-9-11-20(27)12-10-18)25(32-26)19-13-15-28-22(17-19)30-21-7-4-3-5-8-21/h2-5,7-13,15,17H,1,6,14,16H2,(H,28,30)(H,29,33)(H,31,32)
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Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Eberhard Karls University T£bingen

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubat...

J Med Chem 60: 5613-5637 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00316
BindingDB Entry DOI: 10.7270/Q2V98BCK
More data for this
Ligand-Target Pair