BDBM50238252 CHEMBL4061643

SMILES: [H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)Nc1cccc(Br)c1)C(=O)Nc1cn(C(N)=O)c2ccccc12

InChI Key: InChIKey=PVOOIRJEFAYJPX-DPMMWBKBSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50238252   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM50238252 (CHEMBL4061643) Show SMILES [H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)Nc1cccc(Br)c1)C(=O)Nc1cn(C(N)=O)c2ccccc12 |r| Show InChI InChI=1S/C22H20BrN5O3/c23-13-4-3-5-14(10-13)25-20(29)19-9-12-8-18(12)28(19)22(31)26-16-11-27(21(24)30)17-7-2-1-6-15(16)17/h1-7,10-12,18-19H,8-9H2,(H2,24,30)(H,25,29)(H,26,31)/t12-,18-,19+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibition of recombinant human complement factor D catalytic domain using Z-Lys-thiobenzylester as substrate preincubated for 1 hr followed by subst...				J Med Chem 60: 5717-5735 (2017) Article DOI: 10.1021/acs.jmedchem.7b00425 BindingDB Entry DOI: 10.7270/Q2TB195V
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