BindingDB logo
myBDB logout

BDBM50238275 CHEMBL4076955

SMILES: [H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)Nc1cccc(OC(F)(F)F)c1F)C(=O)Cc1cn(C(N)=O)c2ccccc12

InChI Key: InChIKey=RAIHBOSNAXYMNI-PJSAGSTRSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50238275   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Complement factor D


(Homo sapiens (Human))		BDBM50238275
PNG
(CHEMBL4076955)
Show SMILES [H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)Nc1cccc(OC(F)(F)F)c1F)C(=O)Cc1cn(C(N)=O)c2ccccc12 |r|
Show InChI InChI=1S/C24H20F4N4O4/c25-21-15(5-3-7-19(21)36-24(26,27)28)30-22(34)18-9-12-8-17(12)32(18)20(33)10-13-11-31(23(29)35)16-6-2-1-4-14(13)16/h1-7,11-12,17-18H,8-10H2,(H2,29,35)(H,30,34)/t12-,17-,18+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 370n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of recombinant human complement factor D catalytic domain using Z-Lys-thiobenzylester as substrate preincubated for 1 hr followed by subst...

J Med Chem 60: 5717-5735 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00425
BindingDB Entry DOI: 10.7270/Q2TB195V
More data for this
Ligand-Target Pair