BDBM50238423 CHEMBL4080509

SMILES: O=C(N1CCOCC1)c1cccc(Nc2nc3ccccc3n3nnnc23)c1

InChI Key: InChIKey=MITWYWKMDDHITQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50238423   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50238423 (CHEMBL4080509) Show SMILES O=C(N1CCOCC1)c1cccc(Nc2nc3ccccc3n3nnnc23)c1 Show InChI InChI=1S/C19H17N7O2/c27-19(25-8-10-28-11-9-25)13-4-3-5-14(12-13)20-17-18-22-23-24-26(18)16-7-2-1-6-15(16)21-17/h1-7,12H,8-11H2,(H,20,21)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
A GlaxoSmithKline Company Curated by ChEMBL					Assay Description Inhibition of TNKS1 (unknown origin) expressed in HEK293 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in wnt3a ligand-induced...				J Med Chem 60: 5455-5471 (2017) Article DOI: 10.1021/acs.jmedchem.7b00137 BindingDB Entry DOI: 10.7270/Q2X350RS
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50238423 (CHEMBL4080509) Show SMILES O=C(N1CCOCC1)c1cccc(Nc2nc3ccccc3n3nnnc23)c1 Show InChI InChI=1S/C19H17N7O2/c27-19(25-8-10-28-11-9-25)13-4-3-5-14(12-13)20-17-18-22-23-24-26(18)16-7-2-1-6-15(16)21-17/h1-7,12H,8-11H2,(H,20,21)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
A GlaxoSmithKline Company Curated by ChEMBL					Assay Description Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assay				J Med Chem 60: 5455-5471 (2017) Article DOI: 10.1021/acs.jmedchem.7b00137 BindingDB Entry DOI: 10.7270/Q2X350RS
					More data for this Ligand-Target Pair