BDBM50238808 CHEMBL4102642

SMILES: CCN1CCN(CCNc2ncc3cc(-c4cc(OC)cc(OC)c4Cl)c(=O)n(CCc4ccc(NC(=O)C=C)cc4)c3n2)CC1

InChI Key: InChIKey=YBNOWJOKCXLOKC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50238808   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50238808 (CHEMBL4102642) Show SMILES CCN1CCN(CCNc2ncc3cc(-c4cc(OC)cc(OC)c4Cl)c(=O)n(CCc4ccc(NC(=O)C=C)cc4)c3n2)CC1 Show InChI InChI=1S/C34H40ClN7O4/c1-5-30(43)38-25-9-7-23(8-10-25)11-13-42-32-24(19-28(33(42)44)27-20-26(45-3)21-29(46-4)31(27)35)22-37-34(39-32)36-12-14-41-17-15-40(6-2)16-18-41/h5,7-10,19-22H,1,6,11-18H2,2-4H3,(H,38,43)(H,36,37,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
Principia Biopharma, Inc. Curated by ChEMBL					Assay Description In vitro antagonist activity against rat prostatic androgen receptor (AR)				J Med Chem 60: 6516-6527 (2017) Article DOI: 10.1021/acs.jmedchem.7b00360 BindingDB Entry DOI: 10.7270/Q2C53P3H
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50238808 (CHEMBL4102642) Show SMILES CCN1CCN(CCNc2ncc3cc(-c4cc(OC)cc(OC)c4Cl)c(=O)n(CCc4ccc(NC(=O)C=C)cc4)c3n2)CC1 Show InChI InChI=1S/C34H40ClN7O4/c1-5-30(43)38-25-9-7-23(8-10-25)11-13-42-32-24(19-28(33(42)44)27-20-26(45-3)21-29(46-4)31(27)35)22-37-34(39-32)36-12-14-41-17-15-40(6-2)16-18-41/h5,7-10,19-22H,1,6,11-18H2,2-4H3,(H,38,43)(H,36,37,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Principia Biopharma, Inc. Curated by ChEMBL					Assay Description Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...				J Med Chem 60: 6516-6527 (2017) Article DOI: 10.1021/acs.jmedchem.7b00360 BindingDB Entry DOI: 10.7270/Q2C53P3H
					More data for this Ligand-Target Pair