Found 5 hits for monomerid = 50239544 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50239544
(CHEMBL4099101)Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2scc(C)n2c(=O)c1-c1cccc(OCCN(C)C)c1 |r| Show InChI InChI=1S/C25H27N7O2S/c1-15-13-35-21-11-19(16(2)30-24-20(12-26)23(27)28-14-29-24)22(25(33)32(15)21)17-6-5-7-18(10-17)34-9-8-31(3)4/h5-7,10-11,13-14,16H,8-9H2,1-4H3,(H3,27,28,29,30)/t16-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
J Med Chem 60: 5057-5071 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00401
BindingDB Entry DOI: 10.7270/Q2T43W8X |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50239544
(CHEMBL4099101)Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2scc(C)n2c(=O)c1-c1cccc(OCCN(C)C)c1 |r| Show InChI InChI=1S/C25H27N7O2S/c1-15-13-35-21-11-19(16(2)30-24-20(12-26)23(27)28-14-29-24)22(25(33)32(15)21)17-6-5-7-18(10-17)34-9-8-31(3)4/h5-7,10-11,13-14,16H,8-9H2,1-4H3,(H3,27,28,29,30)/t16-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Binding affinity to adenosine A1 receptor of rat brain membranes without NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding |
J Med Chem 60: 5057-5071 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00401
BindingDB Entry DOI: 10.7270/Q2T43W8X |
More data for this
Ligand-Target Pair | |
Phosphoinositide 3-Kinase (PI3K), delta
(Homo sapiens (Human)) | BDBM50239544
(CHEMBL4099101)Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2scc(C)n2c(=O)c1-c1cccc(OCCN(C)C)c1 |r| Show InChI InChI=1S/C25H27N7O2S/c1-15-13-35-21-11-19(16(2)30-24-20(12-26)23(27)28-14-29-24)22(25(33)32(15)21)17-6-5-7-18(10-17)34-9-8-31(3)4/h5-7,10-11,13-14,16H,8-9H2,1-4H3,(H3,27,28,29,30)/t16-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
J Med Chem 60: 5057-5071 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00401
BindingDB Entry DOI: 10.7270/Q2T43W8X |
More data for this
Ligand-Target Pair | |
p110β/p85α
(Homo sapiens (Human)) | BDBM50239544
(CHEMBL4099101)Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2scc(C)n2c(=O)c1-c1cccc(OCCN(C)C)c1 |r| Show InChI InChI=1S/C25H27N7O2S/c1-15-13-35-21-11-19(16(2)30-24-20(12-26)23(27)28-14-29-24)22(25(33)32(15)21)17-6-5-7-18(10-17)34-9-8-31(3)4/h5-7,10-11,13-14,16H,8-9H2,1-4H3,(H3,27,28,29,30)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
J Med Chem 60: 5057-5071 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00401
BindingDB Entry DOI: 10.7270/Q2T43W8X |
More data for this
Ligand-Target Pair | |
p110α/p85α
(Homo sapiens (Human)) | BDBM50239544
(CHEMBL4099101)Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2scc(C)n2c(=O)c1-c1cccc(OCCN(C)C)c1 |r| Show InChI InChI=1S/C25H27N7O2S/c1-15-13-35-21-11-19(16(2)30-24-20(12-26)23(27)28-14-29-24)22(25(33)32(15)21)17-6-5-7-18(10-17)34-9-8-31(3)4/h5-7,10-11,13-14,16H,8-9H2,1-4H3,(H3,27,28,29,30)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
J Med Chem 60: 5057-5071 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00401
BindingDB Entry DOI: 10.7270/Q2T43W8X |
More data for this
Ligand-Target Pair | |
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