Found 5 hits for monomerid = 50239548 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50239548
(CHEMBL4080523)Show SMILES COCCNCc1cccc(Cc2c(cc3scc(C)n3c2=O)[C@H](C)Nc2ncnc(N)c2C#N)c1 |r| Show InChI InChI=1S/C26H29N7O2S/c1-16-14-36-23-11-20(17(2)32-25-22(12-27)24(28)30-15-31-25)21(26(34)33(16)23)10-18-5-4-6-19(9-18)13-29-7-8-35-3/h4-6,9,11,14-15,17,29H,7-8,10,13H2,1-3H3,(H3,28,30,31,32)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
J Med Chem 60: 5057-5071 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00401 BindingDB Entry DOI: 10.7270/Q2T43W8X |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50239548
(CHEMBL4080523)Show SMILES COCCNCc1cccc(Cc2c(cc3scc(C)n3c2=O)[C@H](C)Nc2ncnc(N)c2C#N)c1 |r| Show InChI InChI=1S/C26H29N7O2S/c1-16-14-36-23-11-20(17(2)32-25-22(12-27)24(28)30-15-31-25)21(26(34)33(16)23)10-18-5-4-6-19(9-18)13-29-7-8-35-3/h4-6,9,11,14-15,17,29H,7-8,10,13H2,1-3H3,(H3,28,30,31,32)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of PI3Kdelta in human JeKo1 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 60 mins followed by Anti... |
J Med Chem 60: 5057-5071 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00401 BindingDB Entry DOI: 10.7270/Q2T43W8X |
More data for this Ligand-Target Pair | |
Phosphoinositide 3-Kinase (PI3K), delta
(Homo sapiens (Human)) | BDBM50239548
(CHEMBL4080523)Show SMILES COCCNCc1cccc(Cc2c(cc3scc(C)n3c2=O)[C@H](C)Nc2ncnc(N)c2C#N)c1 |r| Show InChI InChI=1S/C26H29N7O2S/c1-16-14-36-23-11-20(17(2)32-25-22(12-27)24(28)30-15-31-25)21(26(34)33(16)23)10-18-5-4-6-19(9-18)13-29-7-8-35-3/h4-6,9,11,14-15,17,29H,7-8,10,13H2,1-3H3,(H3,28,30,31,32)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.631 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
J Med Chem 60: 5057-5071 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00401 BindingDB Entry DOI: 10.7270/Q2T43W8X |
More data for this Ligand-Target Pair | |
p110α/p85α
(Homo sapiens (Human)) | BDBM50239548
(CHEMBL4080523)Show SMILES COCCNCc1cccc(Cc2c(cc3scc(C)n3c2=O)[C@H](C)Nc2ncnc(N)c2C#N)c1 |r| Show InChI InChI=1S/C26H29N7O2S/c1-16-14-36-23-11-20(17(2)32-25-22(12-27)24(28)30-15-31-25)21(26(34)33(16)23)10-18-5-4-6-19(9-18)13-29-7-8-35-3/h4-6,9,11,14-15,17,29H,7-8,10,13H2,1-3H3,(H3,28,30,31,32)/t17-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
J Med Chem 60: 5057-5071 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00401 BindingDB Entry DOI: 10.7270/Q2T43W8X |
More data for this Ligand-Target Pair | |
p110β/p85α
(Homo sapiens (Human)) | BDBM50239548
(CHEMBL4080523)Show SMILES COCCNCc1cccc(Cc2c(cc3scc(C)n3c2=O)[C@H](C)Nc2ncnc(N)c2C#N)c1 |r| Show InChI InChI=1S/C26H29N7O2S/c1-16-14-36-23-11-20(17(2)32-25-22(12-27)24(28)30-15-31-25)21(26(34)33(16)23)10-18-5-4-6-19(9-18)13-29-7-8-35-3/h4-6,9,11,14-15,17,29H,7-8,10,13H2,1-3H3,(H3,28,30,31,32)/t17-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
J Med Chem 60: 5057-5071 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00401 BindingDB Entry DOI: 10.7270/Q2T43W8X |
More data for this Ligand-Target Pair | |