BDBM50239611 CHEMBL4084290

SMILES: OC[C@@H]1CCN1C(=O)CC1(C2CC3CC(C2)CC1C3)c1ccc(F)cc1

InChI Key: InChIKey=PNVSESWIENVDOX-AOKPMGOMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50239611   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50239611 (CHEMBL4084290) Show SMILES OC[C@@H]1CCN1C(=O)CC1(C2CC3CC(C2)CC1C3)c1ccc(F)cc1 |r,wU:2.1,TLB:18:17:15:11.12.13,8:9:11.18.12:16.14.15,19:9:15:11.12.13,THB:18:12:9.17.16:15,13:12:9:16.14.15,13:14:9:11.18.12,8:9:15:11.12.13,19:9:11.18.12:16.14.15,(33.65,-5.98,;33.96,-7.49,;35.43,-7.96,;36.13,-9.34,;37.5,-8.64,;36.81,-7.26,;37.29,-5.8,;36.04,-4.88,;38.76,-5.32,;39.91,-6.35,;41.11,-5.07,;42.43,-5.56,;43.83,-5.22,;43.85,-3.69,;42.44,-3.11,;41.1,-3.59,;41.4,-4.35,;41.4,-5.94,;42.82,-6.5,;39.89,-7.89,;38.55,-8.64,;38.53,-10.18,;39.86,-10.97,;39.84,-12.51,;41.2,-10.2,;41.21,-8.66,)| Show InChI InChI=1S/C22H28FNO2/c23-19-3-1-16(2-4-19)22(12-21(26)24-6-5-20(24)13-25)17-8-14-7-15(10-17)11-18(22)9-14/h1-4,14-15,17-18,20,25H,5-13H2/t14?,15?,17?,18?,20-,22?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...				J Med Chem 60: 4932-4948 (2017) Article DOI: 10.1021/acs.jmedchem.7b00211 BindingDB Entry DOI: 10.7270/Q2DV1N23
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50239611 (CHEMBL4084290) Show SMILES OC[C@@H]1CCN1C(=O)CC1(C2CC3CC(C2)CC1C3)c1ccc(F)cc1 |r,wU:2.1,TLB:18:17:15:11.12.13,8:9:11.18.12:16.14.15,19:9:15:11.12.13,THB:18:12:9.17.16:15,13:12:9:16.14.15,13:14:9:11.18.12,8:9:15:11.12.13,19:9:11.18.12:16.14.15,(33.65,-5.98,;33.96,-7.49,;35.43,-7.96,;36.13,-9.34,;37.5,-8.64,;36.81,-7.26,;37.29,-5.8,;36.04,-4.88,;38.76,-5.32,;39.91,-6.35,;41.11,-5.07,;42.43,-5.56,;43.83,-5.22,;43.85,-3.69,;42.44,-3.11,;41.1,-3.59,;41.4,-4.35,;41.4,-5.94,;42.82,-6.5,;39.89,-7.89,;38.55,-8.64,;38.53,-10.18,;39.86,-10.97,;39.84,-12.51,;41.2,-10.2,;41.21,-8.66,)| Show InChI InChI=1S/C22H28FNO2/c23-19-3-1-16(2-4-19)22(12-21(26)24-6-5-20(24)13-25)17-8-14-7-15(10-17)11-18(22)9-14/h1-4,14-15,17-18,20,25H,5-13H2/t14?,15?,17?,18?,20-,22?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1				J Med Chem 60: 4932-4948 (2017) Article DOI: 10.1021/acs.jmedchem.7b00211 BindingDB Entry DOI: 10.7270/Q2DV1N23
					More data for this Ligand-Target Pair