BDBM50240137 CHEMBL4062965

SMILES: CN(C)CCCCNC(=O)c1ccc2nnc3-c4ccccc4C(=O)c3c2c1

InChI Key: InChIKey=UAIDUFWAYCKJAS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50240137   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM50240137 (CHEMBL4062965) Show SMILES CN(C)CCCCNC(=O)c1ccc2nnc3-c4ccccc4C(=O)c3c2c1 Show InChI InChI=1S/C22H22N4O2/c1-26(2)12-6-5-11-23-22(28)14-9-10-18-17(13-14)19-20(25-24-18)15-7-3-4-8-16(15)21(19)27/h3-4,7-10,13H,5-6,11-12H2,1-2H3,(H,23,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
National and Kapodistrian University of Athens Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha-mediated kinetoplast DNA decatenation after 60 mins by ethidium bromide staining based agarose gel electroph...				Bioorg Med Chem 25: 2625-2634 (2017) Article DOI: 10.1016/j.bmc.2017.03.019 BindingDB Entry DOI: 10.7270/Q2FQ9ZS6
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