BindingDB PrimarySearch

null

SMILES: NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2F)cc1

InChI Key: InChIKey=OWWHFDSAOSYTOX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50240179
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50240179 (CHEMBL1334282 \| US9962398, Compound MST-141) Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2F)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	7.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against dog gastric proton-pump enzyme H+/K+ ATPase				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50240179 (CHEMBL1334282 \| US9962398, Compound MST-141) Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2F)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	US Patent	7.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50240179 (CHEMBL1334282 \| US9962398, Compound MST-141) Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2F)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	US Patent	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50240179 (CHEMBL1334282 \| US9962398, Compound MST-141) Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2F)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stoppe...				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50240179 (CHEMBL1334282 \| US9962398, Compound MST-141) Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2F)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stoppe...				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50240179 (CHEMBL1334282 \| US9962398, Compound MST-141) Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2F)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	US Patent	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50240179 (CHEMBL1334282 \| US9962398, Compound MST-141) Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2F)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against dog gastric proton-pump enzyme H+/K+ ATPase				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50240179 (CHEMBL1334282 \| US9962398, Compound MST-141) Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2F)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	US Patent	550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair