BDBM50240845 (S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid::2-{(S)-2-[2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-(S)-methyl-pentanoic acid::CHEMBL342252::Neurotensin(8-13)
SMILES: [#6]-[#6]-[#6@@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](-[#8])=O
InChI Key: InChIKey=DQDBCHHEIKQPJD-CSJNAZMVSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neurotensin receptor 1 (MOUSE) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Binding affinity to NTR1 in mouse brain membrane | Bioorg Med Chem Lett 18: 2013-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.110 BindingDB Entry DOI: 10.7270/Q2HM5994 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurotensin receptor 1 (MOUSE) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum) | Bioorg Med Chem Lett 3: 949-952 (1993) Article DOI: 10.1016/S0960-894X(00)80698-8 BindingDB Entry DOI: 10.7270/Q2CJ8DDX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of South Carolina Curated by ChEMBL | Assay Description Binding affinity to human NTR1 | J Med Chem 52: 1803-13 (2009) Article DOI: 10.1021/jm801072v BindingDB Entry DOI: 10.7270/Q2VD6Z9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1 | J Med Chem 47: 5587-90 (2004) Article DOI: 10.1021/jm049644y BindingDB Entry DOI: 10.7270/Q2ZP46VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells | J Med Chem 56: 9361-5 (2013) Article DOI: 10.1021/jm401491e BindingDB Entry DOI: 10.7270/Q2X068H9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurotensin receptor 1 (MOUSE) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity for Neurotensin Receptor | Bioorg Med Chem Lett 5: 997-1002 (1995) Article DOI: 10.1016/0960-894X(95)00155-M BindingDB Entry DOI: 10.7270/Q2GQ6Z76 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells | Bioorg Med Chem 16: 9359-68 (2008) Article DOI: 10.1016/j.bmc.2008.08.051 BindingDB Entry DOI: 10.7270/Q2VT1T0Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.05 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of South Carolina Curated by ChEMBL | Assay Description Displacement of [125I]I-Tyr(3)NT from human NTR1 | J Med Chem 52: 1803-13 (2009) Article DOI: 10.1021/jm801072v BindingDB Entry DOI: 10.7270/Q2VD6Z9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurotensin receptor 2 (Rattus norvegicus) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting | J Med Chem 57: 5318-32 (2014) Article DOI: 10.1021/jm5003843 BindingDB Entry DOI: 10.7270/Q2PR7XJD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurotensin receptor 1 (Rattus norvegicus) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto de Qu£mica M£dica (CSIC) Curated by ChEMBL | Assay Description IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer | J Med Chem 38: 1015-21 (1995) BindingDB Entry DOI: 10.7270/Q2DZ08ZV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurotensin receptor (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of South Carolina Curated by ChEMBL | Assay Description Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 | J Med Chem 46: 4141-8 (2003) Article DOI: 10.1021/jm0300633 BindingDB Entry DOI: 10.7270/Q26M37KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of South Carolina Curated by ChEMBL | Assay Description Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1 | J Med Chem 46: 4141-8 (2003) Article DOI: 10.1021/jm0300633 BindingDB Entry DOI: 10.7270/Q26M37KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurotensin receptor 3 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of South Carolina Curated by ChEMBL | Assay Description Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 3 | J Med Chem 46: 4141-8 (2003) Article DOI: 10.1021/jm0300633 BindingDB Entry DOI: 10.7270/Q26M37KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
Medical University of South Carolina Curated by ChEMBL | Assay Description Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay | J Med Chem 52: 1803-13 (2009) Article DOI: 10.1021/jm801072v BindingDB Entry DOI: 10.7270/Q2VD6Z9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description In vitro inhibition of [3H]-NT binding to human striatal Neurotensin receptor 1 | J Med Chem 47: 5587-90 (2004) Article DOI: 10.1021/jm049644y BindingDB Entry DOI: 10.7270/Q2ZP46VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurotensin receptor 1 (Rattus norvegicus) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0100 | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Agonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay | J Med Chem 57: 5318-32 (2014) Article DOI: 10.1021/jm5003843 BindingDB Entry DOI: 10.7270/Q2PR7XJD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells | Bioorg Med Chem 16: 9359-68 (2008) Article DOI: 10.1016/j.bmc.2008.08.051 BindingDB Entry DOI: 10.7270/Q2VT1T0Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurotensin receptor 2 (Rattus norvegicus) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay | J Med Chem 57: 5318-32 (2014) Article DOI: 10.1021/jm5003843 BindingDB Entry DOI: 10.7270/Q2PR7XJD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM50240845 ((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of South Carolina Curated by ChEMBL | Assay Description Displacement of [125I]I-Tyr(3)NT from human NTR1 | J Med Chem 52: 1803-13 (2009) Article DOI: 10.1021/jm801072v BindingDB Entry DOI: 10.7270/Q2VD6Z9D | |||||||||||
More data for this Ligand-Target Pair |