BDBM50242587 CHEMBL4097866

SMILES: OC1(CCC1)c1cnc(NC(=O)c2ccc(F)c(Cl)c2)s1

InChI Key: InChIKey=ILXVNGJDYBXBLK-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50242587   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Survival motor neuron protein (Homo sapiens)	BDBM50242587 (CHEMBL4097866) Show SMILES OC1(CCC1)c1cnc(NC(=O)c2ccc(F)c(Cl)c2)s1 Show InChI InChI=1S/C14H12ClFN2O2S/c15-9-6-8(2-3-10(9)16)12(19)18-13-17-7-11(21-13)14(20)4-1-5-14/h2-3,6-7,20H,1,4-5H2,(H,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assay				J Med Chem 60: 4594-4610 (2017) Article DOI: 10.1021/acs.jmedchem.6b01885 BindingDB Entry DOI: 10.7270/Q2DF6TM3
					More data for this Ligand-Target Pair