BDBM50243279 5-(5-(1-((4-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl)phenyl)methyl)piperidin-4-yl)-4H-1,2,4-triazol-3-yl)pyridin-2(1H)-one::CHEMBL502113

SMILES: OCCN1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccc(=O)[nH]c2)cc1

InChI Key: InChIKey=FMJIJXDBIQVBDD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50243279   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243279 (5-(5-(1-((4-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-...) Show SMILES OCCN1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C38H40N10O2/c49-21-20-46-16-18-48(19-17-46)38-40-24-31-22-32(27-4-2-1-3-5-27)34(41-35(31)43-38)28-8-6-26(7-9-28)25-47-14-12-29(13-15-47)36-42-37(45-44-36)30-10-11-33(50)39-23-30/h1-11,22-24,29,49H,12-21,25H2,(H,39,50)(H,42,44,45)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) by cellular assay				Bioorg Med Chem Lett 18: 4191-4 (2008) Article DOI: 10.1016/j.bmcl.2008.05.084 BindingDB Entry DOI: 10.7270/Q2RF5TTH
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50243279 (5-(5-(1-((4-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-...) Show SMILES OCCN1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C38H40N10O2/c49-21-20-46-16-18-48(19-17-46)38-40-24-31-22-32(27-4-2-1-3-5-27)34(41-35(31)43-38)28-8-6-26(7-9-28)25-47-14-12-29(13-15-47)36-42-37(45-44-36)30-10-11-33(50)39-23-30/h1-11,22-24,29,49H,12-21,25H2,(H,39,50)(H,42,44,45)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human ERG in embryonic kidney cells by radioligand-binding competition assay				Bioorg Med Chem Lett 18: 4191-4 (2008) Article DOI: 10.1016/j.bmcl.2008.05.084 BindingDB Entry DOI: 10.7270/Q2RF5TTH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243279 (5-(5-(1-((4-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-...) Show SMILES OCCN1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C38H40N10O2/c49-21-20-46-16-18-48(19-17-46)38-40-24-31-22-32(27-4-2-1-3-5-27)34(41-35(31)43-38)28-8-6-26(7-9-28)25-47-14-12-29(13-15-47)36-42-37(45-44-36)30-10-11-33(50)39-23-30/h1-11,22-24,29,49H,12-21,25H2,(H,39,50)(H,42,44,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	284	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) by cellular assay				Bioorg Med Chem Lett 18: 4191-4 (2008) Article DOI: 10.1016/j.bmcl.2008.05.084 BindingDB Entry DOI: 10.7270/Q2RF5TTH
					More data for this Ligand-Target Pair