BDBM50243285 2-(4-(2-phenyl-3-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[3,2-b]pyrazin-6-yl)piperazin-1-yl)ethanol::CHEMBL449989

SMILES: OCCN1CCN(CC1)c1ccc2nc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1

InChI Key: InChIKey=SQYAUXNWQOZSIY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50243285   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243285 (2-(4-(2-phenyl-3-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4...) Show SMILES OCCN1CCN(CC1)c1ccc2nc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C38H40N10O/c49-25-24-46-20-22-48(23-21-46)33-14-13-32-37(41-33)42-35(34(40-32)28-6-2-1-3-7-28)29-11-9-27(10-12-29)26-47-18-15-30(16-19-47)36-43-38(45-44-36)31-8-4-5-17-39-31/h1-14,17,30,49H,15-16,18-26H2,(H,43,44,45)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) by cellular assay				Bioorg Med Chem Lett 18: 4191-4 (2008) Article DOI: 10.1016/j.bmcl.2008.05.084 BindingDB Entry DOI: 10.7270/Q2RF5TTH
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50243285 (2-(4-(2-phenyl-3-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4...) Show SMILES OCCN1CCN(CC1)c1ccc2nc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C38H40N10O/c49-25-24-46-20-22-48(23-21-46)33-14-13-32-37(41-33)42-35(34(40-32)28-6-2-1-3-7-28)29-11-9-27(10-12-29)26-47-18-15-30(16-19-47)36-43-38(45-44-36)31-8-4-5-17-39-31/h1-14,17,30,49H,15-16,18-26H2,(H,43,44,45)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human ERG in embryonic kidney cells by radioligand-binding competition assay				Bioorg Med Chem Lett 18: 4191-4 (2008) Article DOI: 10.1016/j.bmcl.2008.05.084 BindingDB Entry DOI: 10.7270/Q2RF5TTH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243285 (2-(4-(2-phenyl-3-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4...) Show SMILES OCCN1CCN(CC1)c1ccc2nc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C38H40N10O/c49-25-24-46-20-22-48(23-21-46)33-14-13-32-37(41-33)42-35(34(40-32)28-6-2-1-3-7-28)29-11-9-27(10-12-29)26-47-18-15-30(16-19-47)36-43-38(45-44-36)31-8-4-5-17-39-31/h1-14,17,30,49H,15-16,18-26H2,(H,43,44,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) by cellular assay				Bioorg Med Chem Lett 18: 4191-4 (2008) Article DOI: 10.1016/j.bmcl.2008.05.084 BindingDB Entry DOI: 10.7270/Q2RF5TTH
					More data for this Ligand-Target Pair