BDBM50243290 5-(5-(1-((4-(6-(4-methylpiperazin-1-yl)-2-phenylpyrido[3,2-b]pyrazin-3-yl)phenyl)methyl)piperidin-4-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-amine::CHEMBL499961

SMILES: CN1CCN(CC1)c1ccc2nc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccc(N)nc2)cc1

InChI Key: InChIKey=DBNJNPPSWNADBP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50243290   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243290 (5-(5-(1-((4-(6-(4-methylpiperazin-1-yl)-2-phenylpy...) Show SMILES CN1CCN(CC1)c1ccc2nc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccc(N)nc2)cc1 Show InChI InChI=1S/C37H39N11/c1-46-19-21-48(22-20-46)32-14-12-30-37(41-32)42-34(33(40-30)26-5-3-2-4-6-26)27-9-7-25(8-10-27)24-47-17-15-28(16-18-47)35-43-36(45-44-35)29-11-13-31(38)39-23-29/h2-14,23,28H,15-22,24H2,1H3,(H2,38,39)(H,43,44,45)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) by cellular assay				Bioorg Med Chem Lett 18: 4191-4 (2008) Article DOI: 10.1016/j.bmcl.2008.05.084 BindingDB Entry DOI: 10.7270/Q2RF5TTH
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50243290 (5-(5-(1-((4-(6-(4-methylpiperazin-1-yl)-2-phenylpy...) Show SMILES CN1CCN(CC1)c1ccc2nc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccc(N)nc2)cc1 Show InChI InChI=1S/C37H39N11/c1-46-19-21-48(22-20-46)32-14-12-30-37(41-32)42-34(33(40-30)26-5-3-2-4-6-26)27-9-7-25(8-10-27)24-47-17-15-28(16-18-47)35-43-36(45-44-35)29-11-13-31(38)39-23-29/h2-14,23,28H,15-22,24H2,1H3,(H2,38,39)(H,43,44,45)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human ERG in embryonic kidney cells by radioligand-binding competition assay				Bioorg Med Chem Lett 18: 4191-4 (2008) Article DOI: 10.1016/j.bmcl.2008.05.084 BindingDB Entry DOI: 10.7270/Q2RF5TTH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243290 (5-(5-(1-((4-(6-(4-methylpiperazin-1-yl)-2-phenylpy...) Show SMILES CN1CCN(CC1)c1ccc2nc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccc(N)nc2)cc1 Show InChI InChI=1S/C37H39N11/c1-46-19-21-48(22-20-46)32-14-12-30-37(41-32)42-34(33(40-30)26-5-3-2-4-6-26)27-9-7-25(8-10-27)24-47-17-15-28(16-18-47)35-43-36(45-44-35)29-11-13-31(38)39-23-29/h2-14,23,28H,15-22,24H2,1H3,(H2,38,39)(H,43,44,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) by cellular assay				Bioorg Med Chem Lett 18: 4191-4 (2008) Article DOI: 10.1016/j.bmcl.2008.05.084 BindingDB Entry DOI: 10.7270/Q2RF5TTH
					More data for this Ligand-Target Pair