BDBM50244049 (1S,5S)-1-(5-fluorothiophen-2-yl)-3-aza-bicyclo[3.1.0]hexane::CHEMBL453328
SMILES: Fc1ccc(s1)[C@@]12C[C@@H]1CNC2
InChI Key: InChIKey=RVRPCMWCFJXWDX-HZGVNTEJSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Transporter (Rattus norvegicus (rat)) | BDBM50244049 ((1S,5S)-1-(5-fluorothiophen-2-yl)-3-aza-bicyclo[3....) | Reactome pathway UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of norepinephrine uptake at NET in rat brain synaptosome | Bioorg Med Chem Lett 18: 3682-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.077 BindingDB Entry DOI: 10.7270/Q26974G5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50244049 ((1S,5S)-1-(5-fluorothiophen-2-yl)-3-aza-bicyclo[3....) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of dopamine uptake at cloned DAT in rat brain synaptosome | Bioorg Med Chem Lett 18: 3682-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.077 BindingDB Entry DOI: 10.7270/Q26974G5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50244049 ((1S,5S)-1-(5-fluorothiophen-2-yl)-3-aza-bicyclo[3....) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of serotonin uptake at SERT in rat brain synaptosome | Bioorg Med Chem Lett 18: 3682-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.077 BindingDB Entry DOI: 10.7270/Q26974G5 | |||||||||||
More data for this Ligand-Target Pair |