BDBM50244081 (1S,5S)-1-(5-fluorobenzo[b]thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexane::CHEMBL444992
SMILES: Fc1ccc2sc(cc2c1)[C@@]12C[C@@H]1CNC2
InChI Key: InChIKey=CFWHOTMOLFXUOB-NOZJJQNGSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50244081 ((1S,5S)-1-(5-fluorobenzo[b]thiophen-2-yl)-3-aza-bi...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of serotonin uptake at SERT in rat brain synaptosome | Bioorg Med Chem Lett 18: 3682-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.077 BindingDB Entry DOI: 10.7270/Q26974G5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50244081 ((1S,5S)-1-(5-fluorobenzo[b]thiophen-2-yl)-3-aza-bi...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of dopamine uptake at cloned DAT in rat brain synaptosome | Bioorg Med Chem Lett 18: 3682-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.077 BindingDB Entry DOI: 10.7270/Q26974G5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transporter (Rattus norvegicus (rat)) | BDBM50244081 ((1S,5S)-1-(5-fluorobenzo[b]thiophen-2-yl)-3-aza-bi...) | Reactome pathway UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of norepinephrine uptake at NET in rat brain synaptosome | Bioorg Med Chem Lett 18: 3682-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.077 BindingDB Entry DOI: 10.7270/Q26974G5 | |||||||||||
More data for this Ligand-Target Pair |