BDBM50244089 2-(4-Ethylphenyl)-4-(4-(2-(2-(trifluoromethyl)-1Hbenzo[d]imidazol-4-yloxy)ethyl)piperazin-1-yl)-1Hbenzo[d]imidazole::CHEMBL452547

SMILES: CCc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1

InChI Key: InChIKey=QHVQCMAHEGNPBI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50244089   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244089 (2-(4-Ethylphenyl)-4-(4-(2-(2-(trifluoromethyl)-1Hb...) Show SMILES CCc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C29H29F3N6O/c1-2-19-9-11-20(12-10-19)27-33-21-5-3-7-23(25(21)35-27)38-15-13-37(14-16-38)17-18-39-24-8-4-6-22-26(24)36-28(34-22)29(30,31)32/h3-12H,2,13-18H2,1H3,(H,33,35)(H,34,36)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50244089 (2-(4-Ethylphenyl)-4-(4-(2-(2-(trifluoromethyl)-1Hb...) Show SMILES CCc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C29H29F3N6O/c1-2-19-9-11-20(12-10-19)27-33-21-5-3-7-23(25(21)35-27)38-15-13-37(14-16-38)17-18-39-24-8-4-6-22-26(24)36-28(34-22)29(30,31)32/h3-12H,2,13-18H2,1H3,(H,33,35)(H,34,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50244089 (2-(4-Ethylphenyl)-4-(4-(2-(2-(trifluoromethyl)-1Hb...) Show SMILES CCc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C29H29F3N6O/c1-2-19-9-11-20(12-10-19)27-33-21-5-3-7-23(25(21)35-27)38-15-13-37(14-16-38)17-18-39-24-8-4-6-22-26(24)36-28(34-22)29(30,31)32/h3-12H,2,13-18H2,1H3,(H,33,35)(H,34,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair