BDBM50244222 4-(Benzylamino)-2-{[4-(3-hydroxypyrrolidine-1-yl)phenyl]amino}pyrimidine-5-carboxamide::CHEMBL458325

SMILES: NC(=O)c1cnc(Nc2ccc(cc2)N2CCC(O)C2)nc1NCc1ccccc1

InChI Key: InChIKey=XPFHFGPSTXPYCX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50244222   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Signal transducer and activator of transcription 6 (Homo sapiens (Human))	BDBM50244222 (4-(Benzylamino)-2-{[4-(3-hydroxypyrrolidine-1-yl)p...) Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCC(O)C2)nc1NCc1ccccc1 Show InChI InChI=1S/C22H24N6O2/c23-20(30)19-13-25-22(27-21(19)24-12-15-4-2-1-3-5-15)26-16-6-8-17(9-7-16)28-11-10-18(29)14-28/h1-9,13,18,29H,10-12,14H2,(H2,23,30)(H2,24,25,26,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells				Bioorg Med Chem 16: 6509-21 (2008) Article DOI: 10.1016/j.bmc.2008.05.031 BindingDB Entry DOI: 10.7270/Q2VD6Z7H
					More data for this Ligand-Target Pair