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BDBM50244441 1-{6-[4-(2-Methoxycarbonyl-acetyl)-phenoxy]-5-nitro-pyrimidin-4-yl}-piperidine-4-carboxylic acid ethyl ester::CHEMBL487817

SMILES: CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(cc2)C(=O)CC(=O)OC)c1[N+]([O-])=O

InChI Key: InChIKey=WVXNTMHIBPWSRW-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50244441   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))		BDBM50244441
PNG
(1-{6-[4-(2-Methoxycarbonyl-acetyl)-phenoxy]-5-nitr...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(cc2)C(=O)CC(=O)OC)c1[N+]([O-])=O
Show InChI InChI=1S/C22H24N4O8/c1-3-33-22(29)15-8-10-25(11-9-15)20-19(26(30)31)21(24-13-23-20)34-16-6-4-14(5-7-16)17(27)12-18(28)32-2/h4-7,13,15H,3,8-12H2,1-2H3
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Article
PubMed
n/an/an/an/a 1.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair