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BDBM50244588 1-[5-Nitro-6-(4-[1,2,4]triazol-1-yl-phenoxy)-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester::CHEMBL451796

SMILES: CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(cc2)-n2cncn2)c1[N+]([O-])=O

InChI Key: InChIKey=BEQXVWQBFMRYNW-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50244588   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))		BDBM50244588
PNG
(1-[5-Nitro-6-(4-[1,2,4]triazol-1-yl-phenoxy)-pyrim...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(cc2)-n2cncn2)c1[N+]([O-])=O
Show InChI InChI=1S/C20H21N7O5/c1-2-31-20(28)14-7-9-25(10-8-14)18-17(27(29)30)19(23-12-22-18)32-16-5-3-15(4-6-16)26-13-21-11-24-26/h3-6,11-14H,2,7-10H2,1H3
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Article
PubMed
n/an/an/an/a 2.50E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair