BDBM50244768 5-[[4-(2H-Tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone::CHEMBL461940

SMILES: FC(F)(F)c1cccc(c1)N1C(=S)SC(=Cc2ccc(cc2)-c2nnn[nH]2)C1=O

InChI Key: InChIKey=FECPNMXFSNRDOH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50244768   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50244768 (5-[[4-(2H-Tetrazol-5-yl)phenyl]methylene]-2-thioxo...) Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)SC(=Cc2ccc(cc2)-c2nnn[nH]2)C1=O |w:15.16| Show InChI InChI=1S/C18H10F3N5OS2/c19-18(20,21)12-2-1-3-13(9-12)26-16(27)14(29-17(26)28)8-10-4-6-11(7-5-10)15-22-24-25-23-15/h1-9H,(H,22,23,24,25)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human wild type CFTR expressed in rat FRT cells assessed as chloride current by short-circuit current measurements				Bioorg Med Chem 16: 8187-95 (2008) Article DOI: 10.1016/j.bmc.2008.07.044 BindingDB Entry DOI: 10.7270/Q27M07S6
					More data for this Ligand-Target Pair