Found 6 hits for monomerid = 50245517 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50245517
(CHEMBL4086343)Show SMILES Nc1ncnn2c(cc(-c3ccnn3CC(F)(F)F)c12)-c1cccc(c1)N1CCOCC1=O Show InChI InChI=1S/C21H18F3N7O2/c22-21(23,24)11-30-16(4-5-27-30)15-9-17(31-19(15)20(25)26-12-28-31)13-2-1-3-14(8-13)29-6-7-33-10-18(29)32/h1-5,8-9,12H,6-7,10-11H2,(H2,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kbeta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assay |
Bioorg Med Chem Lett 27: 2849-2853 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.077
BindingDB Entry DOI: 10.7270/Q25M684R |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50245517
(CHEMBL4086343)Show SMILES Nc1ncnn2c(cc(-c3ccnn3CC(F)(F)F)c12)-c1cccc(c1)N1CCOCC1=O Show InChI InChI=1S/C21H18F3N7O2/c22-21(23,24)11-30-16(4-5-27-30)15-9-17(31-19(15)20(25)26-12-28-31)13-2-1-3-14(8-13)29-6-7-33-10-18(29)32/h1-5,8-9,12H,6-7,10-11H2,(H2,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta in ACD-treated human whole blood assessed as reduction in IFNgammaX production measured after 1 hr |
Bioorg Med Chem Lett 27: 2849-2853 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.077
BindingDB Entry DOI: 10.7270/Q25M684R |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50245517
(CHEMBL4086343)Show SMILES Nc1ncnn2c(cc(-c3ccnn3CC(F)(F)F)c12)-c1cccc(c1)N1CCOCC1=O Show InChI InChI=1S/C21H18F3N7O2/c22-21(23,24)11-30-16(4-5-27-30)15-9-17(31-19(15)20(25)26-12-28-31)13-2-1-3-14(8-13)29-6-7-33-10-18(29)32/h1-5,8-9,12H,6-7,10-11H2,(H2,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assay |
Bioorg Med Chem Lett 27: 2849-2853 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.077
BindingDB Entry DOI: 10.7270/Q25M684R |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50245517
(CHEMBL4086343)Show SMILES Nc1ncnn2c(cc(-c3ccnn3CC(F)(F)F)c12)-c1cccc(c1)N1CCOCC1=O Show InChI InChI=1S/C21H18F3N7O2/c22-21(23,24)11-30-16(4-5-27-30)15-9-17(31-19(15)20(25)26-12-28-31)13-2-1-3-14(8-13)29-6-7-33-10-18(29)32/h1-5,8-9,12H,6-7,10-11H2,(H2,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assay |
Bioorg Med Chem Lett 27: 2849-2853 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.077
BindingDB Entry DOI: 10.7270/Q25M684R |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50245517
(CHEMBL4086343)Show SMILES Nc1ncnn2c(cc(-c3ccnn3CC(F)(F)F)c12)-c1cccc(c1)N1CCOCC1=O Show InChI InChI=1S/C21H18F3N7O2/c22-21(23,24)11-30-16(4-5-27-30)15-9-17(31-19(15)20(25)26-12-28-31)13-2-1-3-14(8-13)29-6-7-33-10-18(29)32/h1-5,8-9,12H,6-7,10-11H2,(H2,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kgamma (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assay |
Bioorg Med Chem Lett 27: 2849-2853 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.077
BindingDB Entry DOI: 10.7270/Q25M684R |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50245517
(CHEMBL4086343)Show SMILES Nc1ncnn2c(cc(-c3ccnn3CC(F)(F)F)c12)-c1cccc(c1)N1CCOCC1=O Show InChI InChI=1S/C21H18F3N7O2/c22-21(23,24)11-30-16(4-5-27-30)15-9-17(31-19(15)20(25)26-12-28-31)13-2-1-3-14(8-13)29-6-7-33-10-18(29)32/h1-5,8-9,12H,6-7,10-11H2,(H2,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta in ACD-treated human whole blood assessed as reduction in CD69 expression measured after 1 hr |
Bioorg Med Chem Lett 27: 2849-2853 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.077
BindingDB Entry DOI: 10.7270/Q25M684R |
More data for this
Ligand-Target Pair | |
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