BDBM50246539 (R)-3-ethyl-5-(2-(1-methoxypropan-2-yloxy)-5-(4-propylpiperazin-1-ylsulfonyl)pyridin-3-yl)-2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL460294

SMILES: CCCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1

InChI Key: InChIKey=OXYHJDREXPHWMX-MRXNPFEDSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246539   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Canis familiaris)	BDBM50246539 ((R)-3-ethyl-5-(2-(1-methoxypropan-2-yloxy)-5-(4-pr...) Show SMILES CCCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C24H35N7O5S/c1-6-8-30-9-11-31(12-10-30)37(33,34)17-13-18(24(25-14-17)36-16(3)15-35-5)22-26-20-19(7-2)29(4)28-21(20)23(32)27-22/h13-14,16H,6-12,15H2,1-5H3,(H,26,27,32)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of canine retina PDE6 by scintillation proximity assay				Bioorg Med Chem Lett 18: 6033-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.037 BindingDB Entry DOI: 10.7270/Q2H131WT
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50246539 ((R)-3-ethyl-5-(2-(1-methoxypropan-2-yloxy)-5-(4-pr...) Show SMILES CCCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C24H35N7O5S/c1-6-8-30-9-11-31(12-10-30)37(33,34)17-13-18(24(25-14-17)36-16(3)15-35-5)22-26-20-19(7-2)29(4)28-21(20)23(32)27-22/h13-14,16H,6-12,15H2,1-5H3,(H,26,27,32)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay				Bioorg Med Chem Lett 18: 6033-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.037 BindingDB Entry DOI: 10.7270/Q2H131WT
					More data for this Ligand-Target Pair