Found 16 hits for monomerid = 50246774 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human AXL |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human AKT1 |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human CDK2/Cyc2 |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human CDK4/CycD1 |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human MET |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRbeta |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human PLK1 |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human SRC |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human EGFR |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human EPHB4 |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human ERBB2 |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human FAK |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor I receptor
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50246774
(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)Show SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O Show InChI InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of General Genetics
Curated by ChEMBL
| Assay Description Inhibition of human INSR |
J Med Chem 51: 7731-6 (2008)
Article DOI: 10.1021/jm800758s BindingDB Entry DOI: 10.7270/Q2HD7VH4 |
More data for this Ligand-Target Pair | |