BDBM50246874 CHEMBL4095643
SMILES: COc1ccc(cc1C(=O)Nc1ccc(Cl)cc1)C(=O)NO
InChI Key: InChIKey=KNERULXWBNHIGT-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50246874 (CHEMBL4095643) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther University of Halle-Wittenberg Curated by ChEMBL | Assay Description Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in Escherichia coli BL21(DE3) using fluor de Lys(R) as substrate af... | J Med Chem 60: 10188-10204 (2017) Article DOI: 10.1021/acs.jmedchem.7b01447 BindingDB Entry DOI: 10.7270/Q2DZ0BQJ | |||||||||||
More data for this Ligand-Target Pair |