BDBM50247551 4-(5-Chloro-6-fluoroindole-3-yl)-6,7-dimethoxyquinazoline::CHEMBL515401
SMILES: COc1cc2ncnc(-c3c[nH]c4cc(F)c(Cl)cc34)c2cc1OC
InChI Key: InChIKey=CKNICHHQTFEWGN-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50247551 (4-(5-Chloro-6-fluoroindole-3-yl)-6,7-dimethoxyquin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 209 | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universität Berlin Curated by ChEMBL | Assay Description Inhibition of human EGFR tyrosine kinase activity | Eur J Med Chem 43: 1478-88 (2008) Article DOI: 10.1016/j.ejmech.2007.09.018 BindingDB Entry DOI: 10.7270/Q2D50MRC | |||||||||||
More data for this Ligand-Target Pair |