BDBM50247572 (R)-2-((S)-3-(biphenyl-4-yl)-3-methyl-2-oxopyrrolidin-1-yl)-N-hydroxypropanamide::CHEMBL515390

SMILES: C[C@@H](N1CC[C@](C)(C1=O)c1ccc(cc1)-c1ccccc1)C(=O)NO

InChI Key: InChIKey=MCVFKNHXPZRVBQ-VLIAUNLRSA-N

Data: 3 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50247572   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50247572 ((R)-2-((S)-3-(biphenyl-4-yl)-3-methyl-2-oxopyrroli...) Show SMILES C[C@@H](N1CC[C@](C)(C1=O)c1ccc(cc1)-c1ccccc1)C(=O)NO |r| Show InChI InChI=1S/C20H22N2O3/c1-14(18(23)21-25)22-13-12-20(2,19(22)24)17-10-8-16(9-11-17)15-6-4-3-5-7-15/h3-11,14,25H,12-13H2,1-2H3,(H,21,23)/t14-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Affinity towards Matrix metalloprotease-9 (MMP-9)				J Med Chem 45: 4954-7 (2002) BindingDB Entry DOI: 10.7270/Q2XP7497
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50247572 ((R)-2-((S)-3-(biphenyl-4-yl)-3-methyl-2-oxopyrroli...) Show SMILES C[C@@H](N1CC[C@](C)(C1=O)c1ccc(cc1)-c1ccccc1)C(=O)NO |r| Show InChI InChI=1S/C20H22N2O3/c1-14(18(23)21-25)22-13-12-20(2,19(22)24)17-10-8-16(9-11-17)15-6-4-3-5-7-15/h3-11,14,25H,12-13H2,1-2H3,(H,21,23)/t14-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	82	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Affinity for Matrix metalloprotease-2 (MMP-2)				J Med Chem 45: 4954-7 (2002) BindingDB Entry DOI: 10.7270/Q2XP7497
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50247572 ((R)-2-((S)-3-(biphenyl-4-yl)-3-methyl-2-oxopyrroli...) Show SMILES C[C@@H](N1CC[C@](C)(C1=O)c1ccc(cc1)-c1ccccc1)C(=O)NO |r| Show InChI InChI=1S/C20H22N2O3/c1-14(18(23)21-25)22-13-12-20(2,19(22)24)17-10-8-16(9-11-17)15-6-4-3-5-7-15/h3-11,14,25H,12-13H2,1-2H3,(H,21,23)/t14-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.29E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Affinity towards Matrix metalloprotease-1 (MMP-1)				J Med Chem 45: 4954-7 (2002) BindingDB Entry DOI: 10.7270/Q2XP7497
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50247572 ((R)-2-((S)-3-(biphenyl-4-yl)-3-methyl-2-oxopyrroli...) Show SMILES C[C@@H](N1CC[C@](C)(C1=O)c1ccc(cc1)-c1ccccc1)C(=O)NO |r| Show InChI InChI=1S/C20H22N2O3/c1-14(18(23)21-25)22-13-12-20(2,19(22)24)17-10-8-16(9-11-17)15-6-4-3-5-7-15/h3-11,14,25H,12-13H2,1-2H3,(H,21,23)/t14-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
The M. S. University of Baroda Curated by ChEMBL					Assay Description Inhibition of TACE				Bioorg Med Chem 17: 444-59 (2009) Article DOI: 10.1016/j.bmc.2008.11.067 BindingDB Entry DOI: 10.7270/Q2WH2QWZ
					More data for this Ligand-Target Pair
ADAM17 (Sus scrofa (pig))	BDBM50247572 ((R)-2-((S)-3-(biphenyl-4-yl)-3-methyl-2-oxopyrroli...) Show SMILES C[C@@H](N1CC[C@](C)(C1=O)c1ccc(cc1)-c1ccccc1)C(=O)NO |r| Show InChI InChI=1S/C20H22N2O3/c1-14(18(23)21-25)22-13-12-20(2,19(22)24)17-10-8-16(9-11-17)15-6-4-3-5-7-15/h3-11,14,25H,12-13H2,1-2H3,(H,21,23)/t14-,20+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Affinity for Tumor necrosis factor alpha converting enzyme (TACE)				J Med Chem 45: 4954-7 (2002) BindingDB Entry DOI: 10.7270/Q2XP7497
					More data for this Ligand-Target Pair