null

SMILES: Clc1ccc(cc1)-c1cnsc1-c1ccc(Cl)cc1

InChI Key: InChIKey=FCOMTKBRAKMDNZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50247849   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50247849 (4,5-Bis(4-chlorophenyl)isothiazole | CHEMBL491088) Show SMILES Clc1ccc(cc1)-c1cnsc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H9Cl2NS/c16-12-5-1-10(2-6-12)14-9-18-19-15(14)11-3-7-13(17)8-4-11/h1-9H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg-University Curated by ChEMBL					Assay Description Inhibition of COX2 in LPS-stimulated human blood				Bioorg Med Chem 17: 558-68 (2009) Article DOI: 10.1016/j.bmc.2008.11.074 BindingDB Entry DOI: 10.7270/Q2X92B4S
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Bos taurus)	BDBM50247849 (4,5-Bis(4-chlorophenyl)isothiazole | CHEMBL491088) Show SMILES Clc1ccc(cc1)-c1cnsc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H9Cl2NS/c16-12-5-1-10(2-6-12)14-9-18-19-15(14)11-3-7-13(17)8-4-11/h1-9H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg-University Curated by ChEMBL					Assay Description Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLC				Bioorg Med Chem 17: 558-68 (2009) Article DOI: 10.1016/j.bmc.2008.11.074 BindingDB Entry DOI: 10.7270/Q2X92B4S
					More data for this Ligand-Target Pair