Found 7 hits for monomerid = 50248261 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histone deacetylase 8
(Homo sapiens (Human)) | BDBM50248261
(CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)Show InChI InChI=1S/C17H23N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4-7,11-12,21,23H,3,8-10H2,1-2H3,(H,19,22)/b7-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 238 | n/a | n/a | n/a | n/a | n/a | n/a |
Mei Pharma, Inc.
US Patent
| Assay Description The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay. |
US Patent US8551988 (2013)
BindingDB Entry DOI: 10.7270/Q2BZ64P8 |
More data for this Ligand-Target Pair | |
Cereblon/Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50248261
(CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)Show InChI InChI=1S/C17H23N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4-7,11-12,21,23H,3,8-10H2,1-2H3,(H,19,22)/b7-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Mei Pharma, Inc.
US Patent
| Assay Description The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay. |
US Patent US8551988 (2013)
BindingDB Entry DOI: 10.7270/Q2BZ64P8 |
More data for this Ligand-Target Pair | |
Cereblon/Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50248261
(CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)Show InChI InChI=1S/C17H23N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4-7,11-12,21,23H,3,8-10H2,1-2H3,(H,19,22)/b7-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
S *BIO Pte Ltd
Curated by ChEMBL
| Assay Description Inhibition of recombinant HDAC1 by fluorimetric assay |
Bioorg Med Chem Lett 19: 1403-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.041 BindingDB Entry DOI: 10.7270/Q2FT8KX3 |
More data for this Ligand-Target Pair | |
Histone deacetylase 8
(Homo sapiens (Human)) | BDBM50248261
(CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)Show InChI InChI=1S/C17H23N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4-7,11-12,21,23H,3,8-10H2,1-2H3,(H,19,22)/b7-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 238 | n/a | n/a | n/a | n/a | n/a | n/a |
MEI Pharma, Inc.
US Patent
| |
US Patent US10736881 (2020)
|
More data for this Ligand-Target Pair | |
Histone deacetylase 8
(Homo sapiens (Human)) | BDBM50248261
(CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)Show InChI InChI=1S/C17H23N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4-7,11-12,21,23H,3,8-10H2,1-2H3,(H,19,22)/b7-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 238 | n/a | n/a | n/a | n/a | n/a | n/a |
MEI PHARMA, INC.
US Patent
| Assay Description To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20... |
US Patent US10201527 (2019)
BindingDB Entry DOI: 10.7270/Q2PK0J7F |
More data for this Ligand-Target Pair | |
Cereblon/Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50248261
(CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)Show InChI InChI=1S/C17H23N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4-7,11-12,21,23H,3,8-10H2,1-2H3,(H,19,22)/b7-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
MEI Pharma, Inc.
US Patent
| Assay Description The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa... |
US Patent US10736881 (2020)
|
More data for this Ligand-Target Pair | |
Cereblon/Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50248261
(CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)Show InChI InChI=1S/C17H23N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4-7,11-12,21,23H,3,8-10H2,1-2H3,(H,19,22)/b7-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
MEI PHARMA, INC.
US Patent
| Assay Description The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa... |
US Patent US10201527 (2019)
BindingDB Entry DOI: 10.7270/Q2PK0J7F |
More data for this Ligand-Target Pair | |