BDBM50248311 (R)-1-(4-tert-butylphenylsulfonyl)-2-methyl-4-(pyridin-4-ylmethyl)piperazine::CHEMBL473955

SMILES: C[C@@H]1CN(Cc2ccncc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C

InChI Key: InChIKey=WLDFBXGCKXAERK-QGZVFWFLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50248311   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50248311 ((R)-1-(4-tert-butylphenylsulfonyl)-2-methyl-4-(pyr...) Show SMILES C[C@@H]1CN(Cc2ccncc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C |r| Show InChI InChI=1S/C21H29N3O2S/c1-17-15-23(16-18-9-11-22-12-10-18)13-14-24(17)27(25,26)20-7-5-19(6-8-20)21(2,3)4/h5-12,17H,13-16H2,1-4H3/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...				Bioorg Med Chem Lett 19: 1522-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.114 BindingDB Entry DOI: 10.7270/Q2QC03BN
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50248311 ((R)-1-(4-tert-butylphenylsulfonyl)-2-methyl-4-(pyr...) Show SMILES C[C@@H]1CN(Cc2ccncc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C |r| Show InChI InChI=1S/C21H29N3O2S/c1-17-15-23(16-18-9-11-22-12-10-18)13-14-24(17)27(25,26)20-7-5-19(6-8-20)21(2,3)4/h5-12,17H,13-16H2,1-4H3/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPH				Bioorg Med Chem Lett 19: 1522-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.114 BindingDB Entry DOI: 10.7270/Q2QC03BN
					More data for this Ligand-Target Pair