BDBM50248391 2-amino-5-(1-methyl-1H-imidazol-2-ylthio)-N-(4-methylthiazol-2-yl)benzamide::CHEMBL489335

SMILES: Cc1csc(NC(=O)c2cc(Sc3nccn3C)ccc2N)n1

InChI Key: InChIKey=GIQZMGJQUQFLRK-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50248391   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hexokinase-4 (Homo sapiens (Human))	BDBM50248391 (2-amino-5-(1-methyl-1H-imidazol-2-ylthio)-N-(4-met...) Show SMILES Cc1csc(NC(=O)c2cc(Sc3nccn3C)ccc2N)n1 Show InChI InChI=1S/C15H15N5OS2/c1-9-8-22-14(18-9)19-13(21)11-7-10(3-4-12(11)16)23-15-17-5-6-20(15)2/h3-8H,16H2,1-2H3,(H,18,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose				Bioorg Med Chem Lett 19: 1357-60 (2009) Article DOI: 10.1016/j.bmcl.2009.01.053 BindingDB Entry DOI: 10.7270/Q2PC3285
					More data for this Ligand-Target Pair
Hexokinase-4 (Homo sapiens (Human))	BDBM50248391 (2-amino-5-(1-methyl-1H-imidazol-2-ylthio)-N-(4-met...) Show SMILES Cc1csc(NC(=O)c2cc(Sc3nccn3C)ccc2N)n1 Show InChI InChI=1S/C15H15N5OS2/c1-9-8-22-14(18-9)19-13(21)11-7-10(3-4-12(11)16)23-15-17-5-6-20(15)2/h3-8H,16H2,1-2H3,(H,18,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose				Bioorg Med Chem Lett 19: 1357-60 (2009) Article DOI: 10.1016/j.bmcl.2009.01.053 BindingDB Entry DOI: 10.7270/Q2PC3285
					More data for this Ligand-Target Pair