BDBM50248580 6-(4-carbamoylpiperidin-1-yl)-5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)nicotinamide::CHEMBL462874
SMILES: NC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
InChI Key: InChIKey=RDTWLEBCFLFHPB-UHFFFAOYSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thrombopoietin receptor (Homo sapiens (Human)) | BDBM50248580 (6-(4-carbamoylpiperidin-1-yl)-5-chloro-N-(4-(2-flu...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar... | Bioorg Med Chem Lett 19: 1428-30 (2009) Article DOI: 10.1016/j.bmcl.2009.01.032 BindingDB Entry DOI: 10.7270/Q2T43SZN | |||||||||||
More data for this Ligand-Target Pair |